Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival
نویسندگان
چکیده
منابع مشابه
Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival
CLEC16A is in a locus genetically linked to autoimmune diseases including multiple sclerosis, but the function of this gene in the nervous system is unknown. Here we show that two mouse strains carrying independent Clec16a mutations developed neurodegenerative disease characterized by motor impairments and loss of Purkinje cells. Neurons from Clec16a-mutant mice exhibited increased expression o...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep23326